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This characteristic is a vital aspect in understanding Mn transport across the BBB since Mn transporter expression could be different on the apical versus the basolateral side

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Double-blind, placebo-controlled (DBPC) studies have investigated l-carnitine and a multivitamin containing B vitamins, antioxidants, vitamin E, and co-enzyme Q10 while non-blinded studies have investigated ubiquinol

Whether this is by chance, or due to the effect of thyroid growth stimulating antibodies (or other causes) is unknown